J Pharmacol Exp Ther. Oct;(1) Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat. Nielsen CK(1), Ross FB, Smith MT. Author information: (1)School of Pharmacy, The University of Queensland, St. Lucia, Queensland, Australia. Our previous. Incomplete cross-tolerance can lead to greater than anticipated potency in a new opioid, even in the same class of analgesic. Monitor clinical For severe pain, a higher potency opioid agonist (eg, hydromorphone, morphine, fentanyl) can be used. . Oxycodone PO, , , ,
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This is further complicated by the fact that there may be incomplete cross-tolerance between opioids.3,4 This could be due to differences in opioid receptors, occupancy, or efficacy. Though opioid rotation has been associated with improved analgesia, there have been significant side effects during. In the case of converting morphine to methadone, methadone has a relative potency of at lower morphine doses, but becomes much more potent () in patients converting from very high morphine doses.,; Cross-tolerance: Many references recommend a cross-tolerance reduction between %.
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