Bupropion. This drug affects uptake of the neurotransmitters norepinephrine and dopamine and is often used to augment drugs such as SSRIs that act to three previous treatments were able to attain remission after receiving a combination of mirtazapine and extended-release venlafaxine (Effexor). Greater improvement has also been found in patients with affective illness who were treated with a combination of bupropion and a SSRI than with either agent alone (uncontrolled clinical series, Bodkin et al ). In depressed patients who partially responded to lithium augmentation (see below) of SSRI, the further Abstract · Introduction · Antidepressant combinations · Augmenting agents.
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Keywords: Treatment-resistant depression, switching antidepressants, antidepressant polypharmacy, augmentation switches do not appeal to me as much as switching from an SSRI to an SNRI (serotonin-norepinephrine reuptake inhibitor) or to a compound with norepinephrine-dopamine effects (such as bupropion).Summary · Biography. Results: The literature review data is divided into augmentation and combination strategies in descending order of scientific stringency. Bupropion. Bupropion, an antidepressant that is structurally similar to amphetamine, is classified as a norepinephrine and dopamine reuptake inhibitor. Its lack of serotonergic activity.
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